论文部分内容阅读
抗—HAV-IgM一般在黄疸出现时检测到,有时在黄疸前期转氨酶升高时即可检测到。成人抗—HAV-IgM持续时间一般为90～150天,但也有更长时间的报导。作者前瞻性研究观察到儿童和青少年急性HAV感染后高达404天,以确定抗—HAV-IgM的动态变化。对象与方法急性甲型肝炎17例,年龄2～15岁(7.4±4.7岁),诊断是根据临床特征和血清抗—HAV-IgM,所有患儿抗—HBc均为阴性。症状出现4天内采集首次血样。每隔1～3月连续采集血样,直至抗—HAV-IgM阴性。应用固相RIA法Abbot试
Anti-HAV-IgM is usually detected in the presence of jaundice, sometimes detected in the pre-jaundice elevated aminotransferases. Adult anti-HAV-IgM duration is generally 90 to 150 days, but there are more long-term reports. A prospective study of children and adolescents was observed up to 404 days after acute HAV infection to determine the dynamic changes of anti-HAV-IgM. Subjects and Methods Acute hepatitis A (17 cases) aged 2-15 years (7.4 ± 4.7 years) were diagnosed based on clinical features and serum anti-HAV-IgM, all of whom were negative for anti-HBc. The first blood sample was taken within 4 days of symptom onset. Blood samples were collected continuously every 1 to 3 months until anti-HAV-IgM was negative. Application of solid phase RIA Abbot test