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目的探讨反复呼吸道感染患儿血清免疫球蛋白、外分泌液ＳＩｇＡ及外周血淋巴细胞转化率的改变，评价其免疫功能。方法血清免疫球蛋白、Ｃ３，采用免疫比浊法；唾液ＳＩｇＡ采用火箭电泳法；外周血淋巴细胞转化率测定采用３Ｈ－ＴｄＲ渗入法。结果反复呼吸道感染患儿血清ＩｇＧ、ＩｇＡ显著低于正常；外分泌液ＳＩｇＡ水平及外周血淋巴细胞转化率也较正常显著降低。结论反复呼吸道感染患儿存在体液免疫和细胞免疫功能的降低。
Objective To investigate the changes of serum immunoglobulin, exosomal SIgA and peripheral blood lymphocytes in children with recurrent respiratory tract infection and evaluate their immune function. Methods Serum immunoglobulin, C3, immunoturbidimetric method; saliva SIgA using rocket electrophoresis; peripheral blood lymphocyte transformation rate using 3H-TdR infiltration method. Results Serum IgG and IgA in children with recurrent respiratory tract infection were significantly lower than those in normal controls. The level of SIgA in exocrine fluid and the rate of peripheral blood lymphocyte transformation were also significantly lower than those in normal controls. Conclusion There is a decrease of humoral immunity and cellular immunity in children with recurrent respiratory tract infection.