美《自然》杂志第279卷第5714期(1979年6月14日)第638页报道荷兰K.S.Sakariassen等人的研究:止血过程的早期是血小板粘附于内皮下胶原。随后,血小板之间的粘附导致止血栓的形成。认识血浆因子在此过程中的作用是在发现Von Willebrand病病人出血时间延长可用灌输血浆或冷沉淀物加以纠正之后。此血浆因子最初称做Von Willebrand因子,以后鉴定为VIII因子(抗血友病因子A)。现在认为,Von Willebrand因子及VIII因子存在于复合体中,复合体能在某种情况下分离。尽管已有此种进展,关于VIII因子-Von Wille-brand因子复合体(VIII-VWF因子)在止血栓形成中所起的作用,了解得还很少。乔普 Vol. 279, No. 5714 (June 14, 1979), p. 638 Report of K.S Sakariassen et al., The Netherlands: The early stage of hemostasis is the platelet adhesion to subendothelial collagen. Subsequently, the adhesion between platelets leads to the formation of a hemostatic plug. Recognizing the role of plasma factor in this process is to find out that prolonged bleeding in patients with Von Willebrand disease can be corrected by infusion of plasma or cryoprecipitate. This plasma factor was originally called the Von Willebrand factor and later identified as factor VIII (antihemophilic factor A). It is now believed that the Von Willebrand factor and the factor VIII are present in the complex in which the complex can be separated. Despite this progress, little is known about the role of factor VIII-Von Wille-brand factor complex (VIII-VWF factor) in thrombosis. Qiaopu