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目的:观察卡介苗多糖核酸联合异维A酸治疗扁平疣的临床疗效和安全性。方法:70例扁平疣患者随机分为观察组和对照组各35例。对照组口服异维A酸软胶囊10 mg,bid,4周后改为10 mg,qd。观察组在对照组基础上加用卡介苗多糖核酸1 ml,im,隔日一次。治疗8周后,比较两组患者治疗前后T淋巴细胞群和免疫球蛋白水平变化,评价两组临床疗效及不良反应情况。结果:治疗后,两组患者的T细胞群水平、Ig G、Ig A均得到明显改善(P<0.01),且观察组除Ig M外的各项指标改善效果均明显优于对照组(P<0.05)。观察组患者的起效时间明显短于对照组(P<0.01),总有效率明显高于对照组(P<0.05)。两组药品不良反应发生率差异无统计学意义(P>0.05)。结论:卡介苗多糖核酸联合异维A酸软胶囊治疗扁平疣,可显著改善患者的免疫功能状况,提高临床疗效,明显优于单独使用异维A酸。且安全性较高。
Objective: To observe the clinical efficacy and safety of BCG-PSN combined with isotretinoin in the treatment of flat warts. Methods: 70 patients with flat warts were randomly divided into observation group and control group of 35 cases. Control group oral isotretinoin soft capsule 10 mg, bid, 4 weeks later changed to 10 mg, qd. Observation group in the control group based on the use of BCG polysaccharide nucleic acid 1 ml, im, every other day. After 8 weeks of treatment, the changes of T lymphocyte population and immunoglobulin levels in both groups before and after treatment were compared to evaluate the clinical efficacy and adverse reactions of the two groups. Results: After treatment, the levels of T cell, Ig G and Ig A in both groups were significantly improved (P <0.01), and the improvement in each group except Ig M in the observation group was significantly better than that in the control group (P <0.05). The onset time of the observation group was significantly shorter than that of the control group (P <0.01), and the total effective rate was significantly higher than that of the control group (P <0.05). There was no significant difference in the incidence of adverse drug reactions between the two groups (P> 0.05). CONCLUSION: The treatment of flat warts with BCG polysaccharide nucleic acid combined with isotretinoin soft capsule can significantly improve the immune function of patients and improve the clinical curative effect, which is obviously better than that of isotretinoin alone. And high security.