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实验观察铅中毒大鼠海马酸性磷酸酶（ＡＣＰａｓｅ）活性和超微结构的改变，采用了酶组织化学和透射电镜技术。发现（１）实验组海马ＣＡ１、ＣＡ３区和齿状回ＡＣＰａｓｅ活性增强，其中ＣＡ３区图像分析显示，对照组和实验组灰度值分别为 ９９．８０±１．７５和 ８６．４３±１．２９，两组间差异有显著性（Ｐ＜０．０５）；（２）实验组海马 ＣＡ１和 ＣＡ３区锥体细胞细胞器减少，排列稀疏。胞质内出现明显增多的脂褐素。核内出现空泡变性。此外，实验组海马内有髓神经纤维髓鞘出现变形改变。文内还讨论了铅中毒致海马的结构改变对其功能的影响。
Experimental observation of lead poisoning rat hippocampal acid phosphatase (ACPase) activity and ultrastructure changes, using enzyme histochemistry and transmission electron microscopy. The results showed that: (1) The activity of CA1, CA3 and dentate gyrus in the hippocampus of experimental group was enhanced. The image analysis of CA3 showed that the gray value of control group and experimental group were 99.80 ± 1.75 and 86.43 ± 1 respectively. 29, the difference between the two groups was significant (P <0.05). (2) The number of organelles of pyramidal cells in hippocampal CA1 and CA3 areas of experimental group decreased and arranged sparsely. Significant increase in the cytoplasm of lipofuscin. Degeneration of vacuoles in the nucleus. In addition, the experimental group of myelinated fibers in the hippocampus deformities change. The article also discussed the lead poisoning caused by changes in the structure of the hippocampus of its function.