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近年来研究表明,IDDM病人血中含有致糖尿病因子,并证实肝素能和致糖尿病因子结合成稳定的复合物以消除致糖尿病因子的活性。有人给正常动物注射致糖尿病因子可使血糖长期升高;机体对胰岛素的抵抗增强;并且能明显地降低血中胰岛素和肝素的浓度。致糖尿病因子还可抑制血液抗凝系统的活性,使血液的凝固性升高,严重者可形成血栓。本文报道长期应用肝素对IDDM病人的胰岛功能,致糖尿病因子活性及血液抗凝系统的影响。 研究对象及指标:研究对象为19名IDDM病人
In recent years, studies have shown that IDDM patients with blood-induced diabetes, and confirmed that heparin and diabetes-induced factor can be combined into a stable complex to eliminate the activity of diabetes-induced factor. Some people give normal animals injected with diabetes factors can make long-term rise in blood glucose; body resistance to insulin increased; and can significantly reduce the blood insulin and heparin concentrations. Diabetes-induced factor can inhibit the activity of blood anticoagulant system, so that blood coagulation increased, severe cases can form thrombus. This article reports the long-term effects of heparin on islet function, the activity of diabetic agents and the blood anticoagulant system in IDDM patients. Subjects and indicators: The study of 19 IDDM patients