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探索血清ＣＡ１２５在肺癌诊断中的价值。方法：检测了４１例肺癌、１８例良性肺疾病和１５例健康人的血清ＣＡ１２５。随访了１０例肺癌患者经治疗后血清ＣＡ１２５的变化。结果：肺癌组血清ＣＡ１２５高于良性肺疾病组和健康人组。以ＣＡ１２５＞３５Ｕ／ｍｌ为阳性界值，ＣＡ１２５对诊断肺癌的敏感性为５３．７％，若取１００Ｕ／ｍｌ为阳性界值，则敏感性降为３１．７％，而特异性上升为１００％。Ⅰ、Ⅱ期肺癌ＣＡ１２５与良性、健康对照组无显著差异，Ⅲ、Ⅳ期肺癌ＣＡ１２５显著高于对照组。血清ＣＡ１２５增高的１０例肺癌患者经治疗后，ＣＡ１２５浓度降至正常范围内者８例。结论：血清ＣＡ１２５对肺癌有较大的诊断价值。可作为肺癌分期和判断预后的参考指标
To explore the value of serum CA125 in the diagnosis of lung cancer. METHODS: Serum CA125 was detected in 41 patients with lung cancer, 18 with benign lung disease, and 15 healthy subjects. The changes of serum CA125 after treatment in 10 patients with lung cancer were followed up. Results: Serum CA125 levels in lung cancer group were higher than those in benign lung disease group and healthy group. With CA125>35 U/ml as a positive cutoff, the sensitivity of CA125 to the diagnosis of lung cancer was 53.7%. If 100 U/ml was taken as the positive cutoff, the sensitivity decreased to 31.7% and the specificity rose to 100. %. There was no significant difference in CA125 between stage I and II lung cancer and benign and healthy controls. CA125 in stage III and IV lung cancer was significantly higher than that in the control group. After treatment of 10 lung cancer patients with elevated serum CA125, 8 patients whose CA125 concentration fell within the normal range were treated. Conclusion: Serum CA125 has a greater diagnostic value for lung cancer. Can be used as a reference index for lung cancer staging and prognosis