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白细胞介素37(IL-37)是IL-1家族的细胞因子,可在多种细胞中表达。IL-37可通过负反馈免疫调节机制调节先天性和适应性免疫系统,具有抑制炎症反应的作用。在抗感染免疫应答中,IL-37可通过抑制单核细胞、树突状细胞的功能抑制细菌、病毒和真菌等病原生物感染引起的炎症反应,减轻病原体或免疫应答对机体的损伤,从而在感染性休克的防治中发挥作用,另一方面,IL-37也可通过抑制单核巨噬细胞和中性粒细胞等免疫细胞的功能,影响机体抗感染免疫应答,导致病原微生物不能被及时清除,引起持续感染或严重感染,本文就IL-37在感染性疾病中的作用进行综述。
Interleukin-37 (IL-37) is a cytokine of the IL-1 family that is expressed in a wide variety of cells. IL-37 can regulate the innate and adaptive immune system through the negative feedback immunomodulatory mechanism and has the effect of inhibiting the inflammatory reaction. In the anti-infective immune response, IL-37 inhibits the inflammatory response caused by pathogenic infections such as bacteria, viruses and fungi by inhibiting the function of monocytes and dendritic cells and alleviating the pathogen or immune damage to the organism. On the other hand, IL-37 can also affect the body’s anti-infective immune response by inhibiting the function of immune cells such as monocyte-macrophage and neutrophil, resulting in the pathogenic microorganisms can not be cleared in time , Causing persistent infection or serious infection, this article reviews the role of IL-37 in infectious diseases.