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探讨慢性肾功能衰竭(CRF)患者血浆神经肽丫(NP丫)、神经降压素(NT)含量变化与左室肥厚(LVH)的关系。结果发现,患者血浆NP丫较正常对照组显著升高,NT明显降低;CRF合并LVH组及CRF合并高血压组NP丫、左室重量指数均显著高于各自对照组,NT则显著降低;CRF并高血压患者平均动脉压(MAP)与NP丫正相关,与NT负相关,多元回归分析显示NP丫、MAP和NT对LVH作用明显。提示血浆NP丫和NT含量改变可能直接及(或)升高血压间接参与CRF患者LVH形成。
To investigate the relationship between plasma neuropeptide Y (NPY) and neurotensin (NT) levels and left ventricular hypertrophy (LVH) in patients with chronic renal failure (CRF). The results showed that the plasma NPY in patients was significantly higher than the normal control group, NT was significantly reduced; CRF with LVH group and CRF with hypertension group NP Ya, left ventricular mass index were significantly higher than the respective control group, NT was significantly reduced; CRF Mean arterial pressure (MAP) in hypertensive patients was positively correlated with NPY and negatively correlated with NT. Multivariate regression analysis showed that the effects of NPY, MAP and NT on LVH were significant. Suggesting that changes in plasma NP Y and NT levels may directly and / or indirectly lead to elevated blood pressure in patients with CRF LVH formation.