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目的为探讨帕罗西汀对抑郁症的临床疗效及其副反应。方法应用帕罗西汀与阿米替林进行对照治疗研究，采用ＨＡＭＤ、ＴＥＳＳ量表及临床疗效评定标准分别评定疗效及副反应。结果提示帕罗西汀与阿米替林对抑郁症的疗效及显效时间近似；帕罗西汀副反应较阿米替林少且轻微。结论帕罗西汀和阿米替林对抑郁症均有较好的疗效，但帕罗西汀副反应轻微，服药方式简便，患者有较好的依从性，值得临床推广
Objective To investigate the clinical efficacy and side effects of paroxetine in depression. Methods Paroxetine and amitriptyline control study, the use of HAMD, TESS scale and clinical efficacy evaluation criteria were evaluated efficacy and side effects. The results suggest that paroxetine and amitriptyline on the efficacy of depression and effective time similar; paroxetine side effects than amitriptyline less and minor. Conclusion Paroxetine and amitriptyline have a good effect on depression, but paroxetine has minor side effects, convenient mode of administration, patients with better compliance, and worthy of clinical promotion