Objective: To summarize Professor Xie\'s clinical experience in treating the deficiency cold of spleen and stomach type of complex peptic ulcer. Methods: through the observation of the curative effect of the patients with the deficiency cold of spleen and stomach type of complex peptic ulcer in the outpatient department of liver, spleen and stomach department of our hospital, the dialectical application and clinical experience of Professor Xie Jingri\'s self-made prescription in clinical practice were summarized. Results: Professor Xie Jingri\'s self-made prescription can effectively improve the clinical symptoms of patients with the deficiency cold of spleen and stomach type of complex peptic ulcer, and through individual syndrome differentiation and treatment, make the self-made prescription vary from person to person, clinical addition and subtraction, so as to further improve the clinical efficacy of patients. Conclusion: Professor Xie Jingri\'s self-made prescription is effective in treating complex peptic ulcer of spleen stomach deficiency cold type, which is worthy of further clinical application and promotion.