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目的探讨脑梗死患者血浆中C反应蛋白(CRP)的变化规律。方法采用免疫比浊法测定50例脑梗死患者起病1周内、4周时血浆CRP浓度;入院第2d空腹血糖和血脂浓度,并与对照组进行比较,同时把脑梗死患者入院当天按神经功能缺损评分分为轻型组、中型组和重型组3组。结果脑梗死患者起病1周内的CRP浓度明显升高(P<0.01),第4周时CRP浓度有所下降但仍高于正常(P<0.05),中、重2组与轻组比较1周内和4周时的CRP浓度有显著性差异(P<0.01),重型与中型比较CRP浓度也有明显差异(P<0.01);不管是脑梗死组还是对照组50岁以下组和50岁以上组CRP浓度比较无明显差异(P>0.05),合并糖尿病组其CRP和血糖浓度明显高于不合并糖尿病组(P<0.05)。结论CRP参与了脑梗死的炎症反应的病理生理过程,并且病情越重,CRP浓度越高,CRP浓度与年龄无明显关系;脑梗死合并糖尿病时双重作用使CRP升高。
Objective To investigate the changes of plasma C-reactive protein (CRP) in patients with cerebral infarction. Methods 50 cases of cerebral infarction were measured by immunoturbidimetry in 1 week and 4 weeks after onset of plasma CRP concentration; on the 2nd day after admission, fasting blood glucose and blood lipid levels were compared with those of the control group. At the same time, Functional impairment score was divided into light group, medium group and heavy group three groups. Results The level of CRP in the patients with cerebral infarction was significantly higher than that in the control group (P <0.01). The concentration of CRP was decreased but still higher than the normal level in the fourth week (P <0.05) CRP concentrations were significantly different between 1 week and 4 weeks (P <0.01), CRP concentrations were also significantly different between the heavy and medium groups (P <0.01); no matter in cerebral infarction group or control group, There was no significant difference in CRP concentration between the above groups (P> 0.05). The CRP and blood glucose levels were significantly higher in patients with diabetes mellitus than in non-diabetic patients (P <0.05). Conclusion CRP is involved in the pathophysiological process of inflammatory reaction of cerebral infarction. The more serious the disease, the higher the CRP concentration. CRP concentration has no significant relationship with age. CRP increases with the dual action of cerebral infarction and diabetes mellitus.