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硝酸甘油问世,已届百余年之久.因扩张血管而降低心脏的负荷,显示出其对冠心病治疗的良效,早已闻名遐迩.研究家认为:药物扩张血管的作用系通过提高平滑肌细胞中的CGMP水平,从而使血管与其它平滑肌松弛扩张. 硝酸甘油投药途径最常用舌下含服法,收效基快,但持时甚短,生理效应不超过30分钟.因剂量不容易掌握,血中浓度波动,易至低血压和反应心动过速,故其疗效不甚恒定.口服或皮肤给药,虽可延长其作用时间,但药物吸收和可靠性不确,仅适用于病情比较稳定的慢性患者.
Nitroglycerin has come out, has been more than a hundred years ago because of the expansion of blood vessels and reduce the load of the heart, showing its good effect on the treatment of coronary heart disease, has long been famous.Researchers believe that the role of drug dilation of blood vessels by increasing smooth muscle cells In the CGMP level, so that the relaxation of blood vessels and other smooth muscle expansion.Nitroglycerin route of administration most commonly used sublingual method, the effective fast, but very short holding time, the physiological effect of not more than 30 minutes.Because the dose is not easy to grasp, the blood Medium concentration fluctuations, easy to hypotension and reactive tachycardia, so its efficacy is not constant.Oral or dermal administration, although it can extend the role of time, but the drug absorption and reliability is not accurate, only for stable condition Chronic patients.