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目的：观察固本保元浸膏（ＧＥ） 对溃疡性结肠炎大鼠血中超氧化物歧化酶（ＳＯＤ） 、谷胱甘肽过氧化物酶（ＧＳＨ－ Ｐｘ） 及过氧化脂质（ ＭＤＡ） 的影响。方法：对溃疡性结肠炎模型大鼠，给予固本保元浸膏敷脐，以观察大鼠血中自由基的清除能力和过氧化脂质含量。结果：固本保元浸膏能增加血中ＳＯＤ及ＧＳＨ－ Ｐｘ 活性，能降低血中ＭＤＡ含量，与病理对照组比较有显著差异（Ｐ＜ ０．０１） 。结论：固本保元浸膏由于增加了清除自由基的能力，从而提示本药治疗溃疡性结肠炎是有根据的。
Objective: To observe the effect of Guben Baoyuan extract (GE) on blood superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and lipid peroxide (MDA) in rats with ulcerative colitis Impact. METHODS: Ulcerative colitis model rats were treated with Gubenbaoyuan extract and applied to the navel to observe the free radical scavenging capacity and lipid peroxide content in rat blood. Results: Gubenbaoyuan extract could increase the activity of SOD and GSH-Px in blood and reduce the content of MDA in blood, which was significantly different from the pathological control group (P<0.01). Conclusion: Gubenbaoyuan extract has increased the ability to scavenge free radicals, suggesting that the drug is effective in the treatment of ulcerative colitis.