论文部分内容阅读
为了进一步阐明性甾体激素对免疫功能调节作用的机制,荷兰学者 Weusten 等用~(125)Ⅰ标记的雌二醇对人体胸腺细胞和血液单核细胞上是否存在雌激素受体进行了示踪观察,结果发现,在胸腺细胞和单核细胞上均存在低容量和高亲和力的雌二醇结合位点。用未标记的雌二醇可以抑制~(125)Ⅰ-雌二醇对该受体的结合,而雌酮、二氢睾酮、皮质醇和孕激素都无竞争作用。因此,作者认为,该受体与其它靶组织中的雌激素受
In order to further elucidate the mechanism of the regulation of sex steroid hormones on immune function, Weusten et al. Used 125I-labeled estradiol to detect the presence of estrogen receptor on human thymocytes and blood mononuclear cells Observations revealed that both low-volume and high-affinity estradiol binding sites were present on thymocytes and monocytes. Unlabeled estradiol inhibits the binding of ~ (125) I-estradiol to this receptor, whereas estrone, dihydrotestosterone, cortisol, and progestin have no competing effects. Therefore, the authors believe that this receptor is affected by estrogen in other target tissues