1892年Preiffer首先提出内毒素(Endo-toxin)概念,但对它的化学本质是脂多糖(LPS)直到1952年才由wesstphal等证实为革兰氏阴性菌及其它微生物,如衣原体、立克次氏体、螺旋体等细胞壁成份。它对温血动物具有广泛的热效应作用。当肝脏廓清内毒素能力降低时,发生内毒素血症(Endotoxemia)能引起广泛而复杂的病理变比,是医学研究的一项重要内容。 Preiffer first proposed the concept of endo-toxin in 1892, but its chemical nature was that lipopolysaccharide (LPS) was not confirmed to be gram-negative and other microorganisms by wesstphal et al. In 1952, such as chlamydia, Body, spirochetes and other cell wall components. It has a wide range of thermal effects on warm-blooded animals. Endotoxemia can cause a wide range of complex pathological changes when the liver clearance of endotoxin reduced capacity, is an important part of medical research.