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近来认为,母乳具有通过抗炎症机制发挥抗感染作用的特性。而且,对母乳尤其是初乳中存在的大量多形核白细胞和单核吞噬细胞在上述机制中的作用的研究正方兴未艾。本文从母乳吞噬细胞的调理和受体,移动与趋化、杀菌能力这三个方面,对近年来的研究结果作了综述,进而推测,母乳多形核白细胞和单核吞噬细胞与血液中白细胞相比,在形态和功能上的变化可能是母体为了适应乳儿在生理及免疲等方面的新需要,而对母乳吞噬细胞进行“修饰”的结果。
It has recently been suggested that breast milk has the property of exerting an anti-infective effect through an anti-inflammatory mechanism. Moreover, the research on the role of a large number of polymorphonuclear leukocytes and mononuclear phagocytes present in breast milk, especially colostrum, in these mechanisms is in the ascendant. This review summarizes recent studies on the regulation of the phagocytes of human milk and the receptors, motility and chemotaxis, and the bactericidal ability of breast milk phagocytes. Furthermore, it is speculated that the relationship between breast milk polymorphonuclear leukocytes and mononuclear phagocytes and leukocytes In contrast, the morphological and functional changes may be the result of maternal “modification” of breast-milk phagocytes in order to adapt to the new physiological and fatigue-free needs of the infant.