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目的探讨喜炎平联合外用重组人干扰素α-2b喷雾剂治疗小儿手足口病的临床疗效及安全性。方法选择2015年1月至2016年1月在邯郸市第一医院就治的120例手足口病患儿,其中男性57例,女性63例;年龄8个月~4岁,平均年龄2.11岁。随机分为观察组和对照组,每组各60例。对照组单用喜炎平静脉滴注(5~10 mg/kg),每天1次,连续用药5 d;观察组在上述基础上加用重组人干扰素α-2b喷雾剂喷涂于疱疹处,每处1~2喷,每天3次,连续用药5 d。观察两组患儿疱疹消退时间、口腔疼痛缓解时间及患儿一般症状改善情况。结果观察组临床疗效(有效率96.7%)明显优于对照组(有效率91.7%)(P<0.01)。观察组口腔疼痛缓解时间和疱疹消退时间(1.23 d±0.48 d、2.33 d±0.70 d)较对照组(2.67 d±0.84 d、4.05 d±0.46 d)明显缩短(P<0.01),且无明显不适、肝肾损伤等不良反应发生。结论喜炎平联合外用重组人干扰素α-2b喷雾剂治疗小儿手足口病安全有效。
Objective To investigate the clinical efficacy and safety of Xiyanping combined with recombinant human interferon α-2b spray in the treatment of hand-foot-mouth disease in children. Methods From January 2015 to January 2016, 120 cases of hand-foot-mouth disease were treated in Handan First Hospital, including 57 males and 63 females, ranging in age from 8 months to 4 years with a mean age of 2.11 years. Randomly divided into observation group and control group, 60 cases in each group. The control group was treated with Xiyan Ping intravenously (5 ~ 10 mg / kg) once a day for 5 consecutive days. The observation group was treated with the recombinant human interferon α-2b spray on the herpes at the above- Each 1 to 2 spray, 3 times a day, continuous medication 5 d. Two groups of children with herpes subsided time, oral pain relief time and children with general improvement of symptoms. Results The clinical efficacy (effective rate 96.7%) in the observation group was significantly better than that in the control group (effective rate 91.7%) (P <0.01). Oral pain relief time and herpes regression time (1.23 d ± 0.48 d, 2.33 d ± 0.70 d) in the observation group were significantly shorter than those in the control group (2.67 d ± 0.84 d, 4.05 d ± 0.46 d, P <0.01) Discomfort, liver and kidney damage and other adverse reactions. Conclusion Xiyanping combined with topical interferon α-2b spray for the treatment of children with hand-foot-mouth disease is safe and effective.