据报道福尔马林对昆虫、细菌、及酵母菌具有致突作用,对哺乳动物体外实验也显示染色体畸变率增高,但在哺乳动物体内实验中尚未显示增高。Swenbery等报告接触福尔马林气体的哺乳动物鼻咽癌的发病率增高,因此弓I起人们对人类接触福尔马林后果的关注。为评价福尔马林防腐剂对SCE频率的影响,作者对解剖室工作者进行了接触福尔马林防腐剂前后外周血淋巴细胞SCE的分析。 It has been reported that formalin has a mutagenic effect on insects, bacteria, and yeasts. In vitro tests on mammals also show an increase in the rate of chromosome aberrations, but no increase has been shown in mammalian in vivo experiments. Swenbery et al. Reported an increased incidence of nasopharyngeal cancer in mammals exposed to formalin gas and therefore argue that humans are responsible for the consequences of human exposure to formalin. To evaluate the effect of formalin preservatives on the frequency of SCE, the authors performed an analysis of SCE in dissecting room workers before and after exposure to formalin preservatives.