以间二氯苯、正丁酰氯为反应原料,采用傅克反应机理合成2,4-二氯苯丁酮。考察投料比、加料温度、反应温度等因素对2,4-二氯苯丁酮收率的影响;结果表明,最佳反应条件为间二氯苯∶三氯化铝∶正丁酰氯的摩尔比为1.5∶1.5∶1,加料温度40℃、加料时间0.5 h,反应温度110℃,反应时间2 h,最终所得产品的收率可达94.4%。 With dichlorobenzene, n-butyryl chloride as the reaction raw materials, the use of Fu Ke reaction mechanism synthesis of 2,4-dichlorophenylacetone. The effects of feed ratio, feeding temperature and reaction temperature on the yield of 2,4-dichlorophenol were investigated. The results showed that the best reaction conditions were the molar ratio of m-dichlorobenzene to aluminum trichloride to n-butyryl chloride 1.5: 1.5: 1, feeding temperature 40 ℃, feeding time 0.5 h, reaction temperature 110 ℃, reaction time 2 h, the final product yield up to 94.4%.