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背景与目的有许多证据表明表皮生长因子受体Ⅲ型突变体(epidermal growth factor receptor variant typeⅢ,EGFRvⅢ)在一系列恶性肿瘤的发生发展中起重要作用,但EGFRvⅢ与肝癌的关系目前尚未明确。本研究旨在探讨EGFRvⅢ在人肝细胞癌(hepatocellularcarcinoma,HCC)癌组织中的表达,并分析其意义。方法用免疫组化SP方法检测55例HCC癌组织及癌旁肝组织中EGFRvⅢ的表达。结果HCC癌组织中EGFRvⅢ的阳性率(61.8%,34/55)高于癌旁肝组织中的阳性率(38.2%,21/55),两者间有显著性差异(P<0.05)。人肝癌组织中EGFRvⅢ蛋白的检出率与临床分期、门静脉癌栓、肝外转移、术后复发、肿瘤直径大小呈显著性相关,而与肿瘤数目、分化程度、血清AFP水平或HBsAg状况、癌旁肝硬化无显著性相关。结论EGFRvⅢ在肝癌组织中有较高表达,且与肝癌的发展及术后复发等有关。
BACKGROUND & OBJECTIVE: There is a lot of evidence that epidermal growth factor receptor variant type III (EGFRvIII) plays an important role in the development of a series of malignant tumors. However, the relationship between EGFRvIII and hepatocellular carcinoma is not yet clear. This study aimed to investigate the expression of EGFRv Ⅲ in human hepatocellular carcinoma (HCC) and to analyze its significance. Methods Immunohistochemical SP method was used to detect the expression of EGFRv Ⅲ in 55 HCC tissues and adjacent noncancerous liver tissues. Results The positive rate of EGFRvⅢ in HCC tissues was significantly higher than that in adjacent noncancerous liver tissues (61.8%, 34/55) (38.2%, 21/55) (P <0.05). The detection rate of EGFRvIII protein in human hepatocellular carcinoma was significantly correlated with clinical stage, portal vein tumor thrombus, extrahepatic metastasis, postoperative recurrence and tumor diameter, but not with tumor number, differentiation, serum AFP level or HBsAg status No significant correlation between cirrhosis. Conclusion EGFRv Ⅲ is highly expressed in hepatocellular carcinoma and is related to the development of liver cancer and recurrence.