直接应用非修饰的简单氨基醇和氨基酸 ( (S) 吲哚醇和 (S) 吲哚酸 )在硼烷体系中催化前手性酮进行不对称还原。通过反应条件的优化 ,大大增强了手性催化剂的催化能力 ,产物手性二级醇的e .e .值可以达到 82 %～ 87% ,与文献报道的结果相比有了很大的提高 Direct use of unmodified simple amino alcohols and amino acids ((S) indole and (S) indole acids) catalyzed the asymmetric reduction of prochiral ketones in the borane system. By optimizing the reaction conditions, the catalytic ability of the chiral catalyst is greatly enhanced. The e. E. Value of the product chiral secondary alcohol can reach 82% -87%, which is greatly improved compared with the results reported in the literature