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目的研究甲基黄酮醇胺盐对大鼠学习记忆的影响，分析该药影响学习记忆与其影响脑内自由基反应的关系。方法ｉｐ甲基黄酮醇胺盐５，１０ｍｇ·ｋｇ－１共７ｄ后，采用Ｍｏｒ－ｒｉｓ水迷宫测试大鼠的学习记忆能力，同时测定训练ｄ５和休息３０ｄ后大鼠脑内过氧化脂质（ＬＰＯ）含量和超氧化歧化酶（ＳＯＤ）活性。结果甲基黄酮醇胺盐两种剂量均可提高大鼠获取空间定位信息能力和信息贮存能力并增强记忆保持和再现过程。用药大鼠脑内ＬＰＯ含量明显低于对照组，与其记忆成绩呈正相关性。而脑内ＳＯＤ活性则高于对照组，与其记忆成绩呈负相关性。结论甲基黄酮醇胺盐对大鼠的学习记忆机能具有促进作用，而它的抗氧化作用可能为其促进学习记忆的作用机制。
Objective To study the effects of methylflavonolamine on learning and memory in rats and to analyze the relationship between learning and memory and the effects of free radical in brain. Methods Methyl flavonol amine salt 5,10 mg · kg-1 for 7 days, Mor-ris water maze was used to test the learning and memory abilities of rats. At the same time, the levels of lipid peroxidation LPO) content and superoxide dismutase (SOD) activity. Results Methyl flavonol amine salt both can improve the ability of rats to acquire spatial location information and information storage capacity and enhance memory retention and reproduction process. The content of LPO in the brain of the treated rats was significantly lower than that of the control group, which was positively correlated with their memory. While the activity of SOD in brain is higher than that in control group, which is negatively correlated with its memory. Conclusion Methyl flavonolamine salt can promote the learning and memory of rats, and its anti-oxidant effect may be the mechanism of its learning and memory.