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目的 研究糖尿病 (diabetesmellitus ,DM )患者血红蛋白晚期糖基化终末产物 (hemoglobin ad vancedglycosylationendproducts ,Hb AGE)与糖尿病视网膜病变 (diabeticretinopathy ,DR)的关系。 方法 采用竞争性ELISA法检测 12 5例并发或未并发DR的Ⅱ型DM患者的Hb AGE含量 ,并与 5 0例正常对照者比较。 结果 DM患者Hb AGE比正常对照者平均增加 6 5 % ;并发DR者Hb AGE显著高于无DR患者 ;空腹血糖 (fastingplasmaglucoseFPG)水平与Hb AGE含量及DR发生率无直接相关性 ,血压 (BP)、HbA1c及血脂水平与Hb AGE含量和DR发生率有关 (P <0 .0 5 ,或P <0 .0 1)。多因素分析显示DR严重度与Hb AGE关系更为密切 (偏相关系数 =0 .6 0 4,P <0 .0 0 1)。 结论 DM控制与体内血红蛋白晚期糖基化终末产物(hemoglobin advancedglycosylationendproducs ,Hb AGE)含量改变有关 ,AGE大量形成与DR发生和发展有关。
Objective To investigate the relationship between hemoglobin, advanced glycation end products (Hb AGE) and diabetic retinopathy (DR) in patients with diabetesmellitus (DM). Methods Hb AGE levels in 125 type Ⅱ DM patients with or without concurrent DR were measured by competitive ELISA and compared with 50 normal controls. Results The Hb AGE in DM patients increased by 65% on average compared with that in controls. The Hb AGE in patients with DR was significantly higher than that in non-DR patients. The fasting plasma glucose (FPG) level had no direct correlation with Hb AGE level and DR incidence, , HbA1c and blood lipid level were related to the content of Hb AGE and the incidence of DR (P <0.05 or P <0.01). Multivariate analysis showed that DR severity was more closely related to Hb AGE (partial correlation coefficient = 0.604, P <0.001). Conclusion DM control is related to the change of hemoglobin advanced glycosylation end products (Hb AGE) in vivo. The formation of AGE is related to the occurrence and development of DR.