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目的观察急性脑梗死(ACI)患者血清S-100b蛋白和基质金属蛋白酶-2(MMP-2)含量的变化,探讨其在ACI发病中的作用及临床意义。方法选取56例ACI病例为患者组,30例健康体检者为对照组。采用ELISA法动态监测血清S-100b蛋白和MMP-2的浓度,并用SPSS17.0统计软件进行统计学分析。结果患者组血清S-100b蛋白和MMP-2水平均明显高于对照组,差异有统计学意义(P<0.05),S-100b蛋白浓度于发病后第3天达高峰,MMP-2浓度于发病后第7天达高峰,之后浓度逐渐降低。S-100b蛋白和MMP-2与脑梗死体积大小和损伤程度存在相关性(P<0.05)。结论 ACI患者脑血清S-100b蛋白和MMP-2浓度能敏感地反映患者梗死体积和神经功能损伤程度,是ACI临床诊断、病情监测和疗效观察的重要参数。
Objective To observe the changes of serum S-100b protein and matrix metalloproteinase-2 (MMP-2) in patients with acute cerebral infarction (ACI), and to explore its role in the pathogenesis of ACI and its clinical significance. Methods Fifty-six patients with ACI were selected as the patient group and 30 healthy individuals as the control group. Serum levels of S-100b protein and MMP-2 were detected by ELISA. Statistical analysis was performed using SPSS17.0 statistical software. Results The serum levels of S-100b and MMP-2 in patients were significantly higher than those in control group (P <0.05). The protein level of S-100b peaked on the third day after onset, After reaching the peak on the 7th day after onset, the concentration gradually decreased. The correlation between S-100b protein and MMP-2 and cerebral infarction volume and degree of injury (P <0.05). Conclusions The serum S-100b protein and MMP-2 concentration in ACI patients can reflect the infarction volume and the degree of neurological impairment sensitively. It is an important parameter for clinical diagnosis, condition monitoring and curative effect observation of ACI.