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[目的]探讨人乳头瘤病毒(humanpa pillomavirus,HPV)感染与中国女性乳腺癌患病之间的危险性。[方法]计算机检索Pubmed、CNKI数据库、万方数据库,利用文献追溯等途径收集1989年8月至2011年10月国内外公开发表的有关HPV感染与中国女性乳腺癌患病的相关文献,应用Meta分析对其进行综合评价。[结果]30篇文献符合纳入标准,其中病例对照研究26篇。中国人群乳腺癌患者中HPV的总感染率为49.64%(95%CI:47.09%～52.19%)。随机效应模型计算结果显示,中国人群中HPV感染与乳腺癌发病间存在关联,OR值为2.68(95%CI:2.03～3.54),但存在发表偏倚。[结论]中国女性乳腺癌与HPV感染有一定关联,其机制有待进一步的生物学研究。
[Objective] To explore the risk of human papillomavirus (HPV) infection and the prevalence of breast cancer in Chinese women. [Methods] Pubmed, CNKI database and Wanfang database were searched by computer, and the related literature about HPV infection and breast cancer in Chinese women published from August 1989 to October 2011 were collected. Meta Analysis of its comprehensive evaluation. [Results] Thirty articles met the inclusion criteria, of which 26 were case-control studies. The total infection rate of HPV in Chinese breast cancer patients was 49.64% (95% CI: 47.09% -52.19%). The results of random effects model showed that there was a correlation between HPV infection in Chinese population and the incidence of breast cancer, OR was 2.68 (95% CI: 2.03 ~ 3.54), but there was publication bias. [Conclusion] There is a certain relationship between breast cancer and HPV infection in Chinese women, and its mechanism needs further biological studies.