论文部分内容阅读
本文用ABG免疫组化染色技术观察了P物质（SP）、降钙素基因相关胜（CGRP）、神经肽Y（NPY）等多种神经肽类物质在变应性皮炎和正常皮肤的发生及分布。结果发现：在变应性皮炎皮损的真皮浅层SP、CGRP类物质明显增加，正常皮肤中无此现象；在变应性皮炎和正常皮肤的小开腺周围及开腺导管管壁上，SP、CGRP及NPY均有不同形式的阳性染色。SP可促使皮肤肥大细胞释放组织胺等炎性介质，后者可引起血管扩张，通透性增强；CGRP则直接作用于小血管壁使之舒张，细胞成分外渗，二者均能加重局部炎性细胞浸润。作者认为：在迟发性变态反应性皮炎的发病机制中，神经胜至少作为炎性介质参与了发病过程。
In this study, ABG immunohistochemistry was used to observe the occurrence of allergic dermatitis and normal skin of various neuropeptide substances such as substance P (SP), CGRP, NPY and so on distributed. The results showed that: in the dermis of allergic dermatitis skin superficial SP, CGRP substances significantly increased in normal skin without this phenomenon; in the allergic dermatitis and normal skin around the small gland and open gland duct wall, SP, CGRP and NPY have different forms of positive staining. SP can promote skin mast cells release histamine and other inflammatory mediators, the latter can cause vasodilation and permeability increased; CGRP is a direct role in the small blood vessel wall so that relaxation, cell components of extravasation, both of which can aggravate local inflammation Sexual cell infiltration. Authors believe that: in the pathogenesis of delayed-type allergic dermatitis, nerve wins at least as an inflammatory mediator involved in the pathogenesis.