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目的：探讨血浆P－选择素和IL－8的测定在急性呼吸窘迫综合征（ARDS）中的临床价值。方法：分别采用放免法和酶联免疫吸附法检测25例ARDS患者血浆P－选择素和IL－8，同时行APACHEⅡ评分。结果：ARDS患者血浆P－选择素和IL－8明显高于正常对照组（P＜0．01），且随着APACHEⅡ评分增高，P－选择素也明显增高，两者呈正相关（P＜0．01）；死亡患者血浆P－选择素、IL－8及APACHEⅡ评分均显著高于存活患者（P＜0．05）；综合治疗后，存活患者P-选择素和LT－8下降（P＜0．05）。结论：P－选择素和IL－8可能参与了ARDS的发病，测定血循环P－选择素和IL－8的水平，并结合APACHEⅡ评分可作为判断ARDS病情严重程度的参考指标。
Objective: To investigate the clinical value of plasma P-selectin and IL-8 in acute respiratory distress syndrome (ARDS). Methods: The plasma P-selectin and IL-8 in 25 ARDS patients were detected by radioimmunoassay and enzyme-linked immunosorbent assay, respectively. APACHEⅡscore was also performed. Results: The plasma levels of P-selectin and IL-8 in patients with ARDS were significantly higher than those in normal controls (P <0.01), and P-selectin was also significantly increased with APACHEⅡscore .01). The plasma levels of P-selectin, IL-8 and APACHEⅡ in patients with death were significantly higher than those in survivors (P <0.05). After treatment, P-selectin and LT- 0.05). CONCLUSION: P-selectin and IL-8 may be involved in the pathogenesis of ARDS. The levels of P-selectin and IL-8 in blood circulation may be measured. Combined with APACHEⅡscore, it may be used as a reference index to determine the severity of ARDS.