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糖尿病是一种超出目前的Ⅰ型(胰岛素依赖)和Ⅱ型(非胰岛素依赖)分类所包含的异质性疾病。为了显示疾病异质性对Ⅱ型糖尿病胰岛素分泌作用下降相关作用的影响,我们对Bomia研究中的一大群携有GADA或MODY突变者,在行OGTT期间评价了其胰岛素分泌和胰岛素敏感性。并通过正常血糖钳术和静脉内糖耐量实验评价了研究对象中一个亚群的胰岛素分泌和胰岛素敏感性。
Diabetes mellitus is a heterogeneous disease beyond the current type I (insulin dependent) and type II (non-insulin dependent) classifications. To demonstrate the effect of disease heterogeneity on the declining role of insulin secretion in type 2 diabetes, we evaluated a large population of patients with GADA or MODY mutations in the Bomia study who were assessed for insulin secretion and insulin sensitivity during OGTT. The insulin secretion and insulin sensitivity of one subpopulation of subjects were assessed by normal blood glucose clamp and intravenous glucose tolerance test.