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采用Ｙ－迷宫分辨学习和一次被动回避反应两种行为模型，利用小鼠海马内微注射技术，检测了钙通道拮抗剂尼莫地平的中枢效应，并观察了开场行为，利用ＳＮＫ法及Ｋｒｕｓｋａｌ－ＷａｌｉｓＨ检验法处理实验数据，结果表明，海马内钙离子水平升高会破坏小鼠的分辨学习能力及一次被动回避反应的记忆保持。尼莫地平本身对正常小鼠的分辨学习无明显影响，但可促进小鼠一次被动回避反应的记忆保持，并可对抗海马内Ｃａ２＋水平升高引起的小鼠分辨学习障碍及记忆保持的破坏。
Y-maze discrimination learning and passive avoidance reaction were used to detect the central effect of the calcium channel antagonist nimodipine by microinjection into the hippocampus of mice. The opening behavior was also observed. SNK and Kruskal- WalisH test data processing experimental results show that increased levels of calcium in the hippocampus will disrupt the ability of mice to distinguish learning and memory retention of a passive avoidance response. Nimodipine itself has no obvious effect on the discrimination learning of normal mice, but it can promote the memory retention of passive anaphylactic reaction in mice and antagonize the damage of learning disability and memory retention in mice induced by elevated Ca2 + in hippocampus.