许多实验和临床研究已经证实,硝酸甘油(NTG)的血管扩张作用至少有部分是由于前列腺素(PG)的释放。阿司匹林抑制PG的合成和释放,可减弱NTG的药理作用,但随剂量而有所不同。本研究是探讨不同剂量的阿司匹林对舌下NTG血液动力学的影响。7例21～30岁的正常男性志愿者,全部经过临床常规检查,描记休息时的心电图及常规的生物数据,包括舒张压、心率、左室舒张末期和收缩末期直 Numerous experimental and clinical studies have demonstrated that the vasodilatory effect of nitroglycerin (NTG) is due at least in part to the release of prostaglandin (PG). Aspirin inhibits the synthesis and release of PG, which attenuates the pharmacological effects of NTG, but varies with dose. This study was to investigate the effect of different doses of aspirin on hemodynamics of sublingual NTG. Seven normal male volunteers aged 21 to 30 years old, all through routine clinical examination, electrocardiogram at rest and conventional biological data, including diastolic blood pressure, heart rate, left ventricular end-diastolic and end-systolic