论文部分内容阅读
目的:观察密闭舱室内亚致死剂量爆炸伤大鼠额叶皮质及血浆内单胺神经递质的变化对大鼠旷场行为的影响。方法:采用密闭舱室内亚致死剂量爆炸伤的大鼠模型,高效液相色谱电化学法分析大鼠血浆、额叶皮质内5-羟色胺(5-HT)、多巴胺(DA)、肾上腺素(E)、去甲肾上腺素(NE)含量的变化,用旷场行为观察箱观察大鼠旷场行为。结果:舱内亚致死剂量爆炸伤大鼠额叶皮质内NE、E含量较对照组明显升高(P<0.05),DA含量明显降低(P<0.05),5-HT的含量在爆炸后48 h达高峰,随后出现下降,密闭舱室内亚致死剂量爆炸后大鼠旷场行为较对照组明显减少(P<0.05)。结论:舱内爆炸后大鼠的兴奋性明显下降;大鼠旷场行为与舱内爆炸后额叶皮质E浓度呈负相关(r=-0.987,P<0.05),与5-HT浓度呈正相关(r=0.952,P<0.05);大鼠旷场行为与血浆内E浓度呈正相关(r=-0.979,P<0.05),而与5-HT的浓度成负相关(r=-0.958,P<0.05)。
OBJECTIVE: To observe the effects of changes of monoamine neurotransmitters in frontal lobe cortex and plasma on the open-field behavior of rat after exposure to sub-lethal dose explosion in airtight rats. Methods: The rat model of sub-lethal dose explosion injury in airtight compartments was established. The contents of 5-hydroxytryptamine (5-HT), dopamine (DA), epinephrine ), Norepinephrine (NE) content changes in open-field behavior observation box observed open-field behavior. Results: The contents of NE and E in the frontal cortex of rats exposed to sublethal radiation in the cabin were significantly higher than those in the control group (P <0.05), while the content of DA was significantly decreased (P <0.05) h, then decreased. The open field behavior of rats after exposure to sub-lethal dose in the aseptic cabin was significantly lower than that of the control group (P <0.05). CONCLUSION: The excitability of rats after in-flight explosion was significantly decreased. The open-field behavior of rats was negatively correlated with the E concentration of frontal cortex in rats (r = -0.987, P <0.05), which was positively correlated with the concentration of 5-HT (r = 0.952, P <0.05). There was a positive correlation between open field behavior and plasma E concentration (r = -0.979, P <0.05) and negative correlation with 5-HT <0.05).