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目的观察熊去氧胆酸(UDCA)治疗药物性肝损伤(DILI)的疗效。方法288例临床诊断DILI患者分为2组,治疗组144例采用保肝降酶加UDCA(750mg/d)治疗(A组),对照组144例采用保肝降酶治疗(B组),观察比较2组间临床症状、体征的改善和肝功能生化指标的恢复情况。结果乏力、呕吐症状的改善A组较B组明显(0.0062和0.0344);在生化方面DBil、GGT下降明显优于B组(0.0016和0.0073),优效性检验(B组为对照)TBil、DBil两组差值有明显差异(0.0026和0.0002);在胆汁淤积型和混合型患者中治疗前后的TBil、DBil、GGT差值差异有统计学意义(0.0002、0.0000和0.0008)。结论UDCA可有效治疗DILI,尤其是对那些胆汁淤积型和混合型患者更为合适。
Objective To observe the efficacy of ursodeoxycholic acid (UDCA) in the treatment of drug-induced liver injury (DILI). Methods 288 cases of clinical diagnosis of DILI patients were divided into two groups, the treatment group of 144 patients with liver enzymes plus UDCA (750mg / d) treatment (A group), the control group of 144 patients with hepatoprotective therapy (B group), observation The clinical symptoms, signs and signs of recovery and the recovery of liver biochemical indicators were compared between the two groups. Results The improvement of fatigue and vomiting in group A was significantly higher than that in group B (0.0062 and 0.0344). The biochemical DBil and GGT decreased significantly more than those in group B (0.0016 and 0.0073), the superiority test (group B) TBil and DBil There was significant difference between the two groups (0.0026 and 0.0002). The difference of TBil, DBil and GGT before and after treatment in patients with cholestasis and mixed type was statistically significant (0.0002, 0.0000 and 0.0008). Conclusion UDCA can effectively treat DILI, especially for those patients with cholestasis and mixed type.