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Annexins家族是钙依赖性磷脂结合蛋白,可以分为A、B、C、D和E 5组。它们结构上表现为同源相似性的钙依赖性磷脂结合蛋白,含有一个C端核心区域和一个可变N端结构域,前者可与膜相关磷脂结合,后者决定了不同Annexins蛋白的特性。Annexins家族成员参与抗凝血、抗炎、出胞、入胞作用、信号转导、细胞增殖、分化和凋亡等多种生理活动,并与多种恶性肿瘤的发生、发展、浸润及转移密切相关,为肿瘤早期诊断、治疗及预后判断提供线索。
The Annexins family is a calcium-dependent phospholipid-binding protein that can be divided into groups A, B, C, D and E5. Their structurally homologous similarity of calcium-dependent phospholipid-binding protein, containing a C-terminal core region and a variable N-terminal domain, the former can be associated with membrane-associated phospholipids, the latter determines the properties of different Annexins proteins. Annexins family members participate in a variety of physiological activities such as anticoagulant, anti-inflammation, exocytosis, cell entry, signal transduction, cell proliferation, differentiation and apoptosis, and are closely related to the occurrence, development, infiltration and metastasis of many malignant tumors Related to early diagnosis, treatment and prognosis of clues to provide clues.