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糖尿病(DM)是一种慢性内分泌代谢紊乱疾病,以葡萄糖和脂类代谢异常为特征。随着现代人生活方式及饮食结构的改变,糖尿病呈现全球化、年轻化的趋势。统计~([1])表明,全球糖尿病患者已超过3亿,90%以上为2型糖尿病,预测到2030年,患病人数将超过4亿。肝糖输出增多是造成糖尿病患者空腹血糖升高的主要因素,且肝糖输出主要依赖于肝糖异生。肝脏激酶B1(LKB1)是机体能量不足状态下调节AMP活化蛋白激酶(AMPK)的主要酶体,可在胞浆内活化AMPK调节下游糖异生关键分子环磷酸腺苷反应
Diabetes mellitus (DM) is a chronic disorder of endocrine and metabolic disorders characterized by abnormal glucose and lipid metabolism. With the change of modern life style and diet structure, diabetes shows a tendency of globalization and younger age. Statistics ~ ([1]) shows that more than 300 million people worldwide have diabetes and more than 90% have type 2 diabetes. It is predicted that by 2030, the number of patients suffering illness will exceed 400 million. Increased hepatic glucose output is the main cause of fasting blood glucose in diabetic patients, and liver glycogen output mainly depends on glycogen. Liver Kinase B1 (LKB1) is the main regulator of AMP-activated protein kinase (AMPK) under the condition of insufficient energy in the body. It can activate AMPK in the cytoplasm to regulate downstream glycoprotein adenosine reaction