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美国威斯康星大学医学院前瞻性研究立体放射外科(SR)对脑转移瘤的作用。1988年12月～1991年3月共收治40例病人,KPS均大于50%,共58处转移灶,其中30例为单发,6例为放射敏感肿瘤(1例小细胞肺癌,5例淋巴瘤),12例位于幕下,其余为幕上。15例为外照射后复发病例(平均时间12个月),25例为作为全脑外照射的追加剂量进行SR治疗的,其外照射剂量平均为30Gy/10次。设备包括加速器、固定系统、三维显象系统、剂量监测、靶定位、治疗计划、质控系统等。4例用两个等中心照射,其余皆为一个等中心,准直器大小为1.0～4.0cm,平均2.5cm,肿瘤直径0.25～0.5cm,包括在80%等剂量曲线内,平均剂量25Gy。平均随访时间为6.5个月,其中14例随访9个月以上。
University of Wisconsin Medical School Prospective study of stereotactic radiosurgery (SR) on brain metastases. From December 1988 to March 1991, a total of 40 patients were enrolled in this study. The KPS was greater than 50% with a total of 58 metastases, of which 30 were solitary and 6 were radiosensitive (1 small cell lung cancer, 5 lymphoid Tumor), 12 cases located in the screen, the rest of the screen. Fifteen patients were relapsed after external irradiation (mean time, 12 months), and 25 patients were treated with SR as an additional dose of whole brain irradiation. The average external dose was 30 Gy / 10 times. Equipment includes accelerators, fixed systems, 3D imaging systems, dose monitoring, target positioning, treatment planning, quality control systems and more. 4 cases were irradiated with two isocenters and the others were all one isocenter. The size of the collimator was 1.0-4.0 cm with an average of 2.5 cm and the diameter of the tumor was 0.25-0.5 cm. The average dose was 25 Gy contained in the 80% isodose curve. The average follow-up time was 6.5 months, of which 14 cases were followed up for more than 9 months.