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目的探讨内科病区老年患者用药中的药物相互作用情况。方法查阅电子病历,将2014年10月—2015年6月宁波市妇女儿童医院内科病区收治入院的老年(年龄≥65周岁)患者纳入研究对象,并对其用药情况进行回顾性调查研究,以药品说明书为依据,评判其是否存在药物相互作用,并对可能由其导致的药物不良事件进行统计分析。结果共163例老年患者纳入研究,医嘱用药中位数是7,潜在的药物相互作用中位数是3,94例患者存在有临床意义的潜在的药物相互作用,占57.7%;临床发生实际药物相互作用有10例,占6.1%,其中8例发生药物不良反应,2例发生药物疗效欠佳。结论为了保障老年患者用药安全,医师应关注药物的相互作用,尽量减少用药品种数和避免选择相互作用有害的药物以降低药物不良事件的发生率。
Objective To explore the drug interactions in elderly patients in medical wards. Methods The electronic medical records were reviewed. The aged (≥65 years old) admitted to Ningbo Womens and Children’s Hospital from October 2014 to June 2015 were enrolled in the study, and their medication was retrospectively studied. Drug manual as the basis for judging whether there is a drug interaction, and the possible adverse drug events caused by statistical analysis. RESULTS: A total of 163 elderly patients were enrolled in the study, with a median doctor’s order of 7, and a median potential drug interaction of 3,94 patients with clinically significant potential drug interactions, accounting for 57.7%. The actual clinical drug Interaction in 10 cases, accounting for 6.1%, of which 8 cases of adverse drug reactions, 2 cases of poor efficacy of the drug. Conclusion In order to ensure the safety of elderly patients, physicians should pay attention to the interaction of drugs, minimize the number of drugs used and avoid selecting harmful drugs to reduce the incidence of adverse drug events.