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目的评估中国居民成人饮白酒者(以下简称饮酒者)抗雄激素作用样邻苯二甲酸酯类物质,即邻苯二甲酸二(2-乙基己基)酯(DEHP)、邻苯二甲酸二丁酯(DBP)、邻苯二甲酸丁基苄基酯(BBP)的累积膳食摄入水平及其健康风险。方法利用2011—2013年间收集的24类食品中DEHP、DBP和BBP含量数据,结合2002年中国居民营养与健康状况调查数据,采用简单分布评估的方法,计算我国居民成人饮酒者全人群以及18~59岁(男、女)、60岁以上(男、女)等4个不同性别-年龄组人群DEHP、DBP和BBP的膳食摄入水平。采用危害指数法计算经膳食联合暴露于DEHP、DBP和BBP的健康风险。结果单一化学物的风险评估发现,我国成人饮酒者中全人群和各性别-年龄组人群的DEHP、DBP和BBP的平均摄入量和高食物消费量人群(P97.5)的摄入量均低于其相应的每日可耐受摄入量(TDI)。进一步分析发现,约有0.64%(18/2 800)的个体DBP摄入量超过其TDI。而采用危害指数方法进行的累积风险评估发现,我国成人饮酒者全人群和各性别-年龄组人群的危害指数均低于1;有0.79%(22/2 800)的个体危害指数超过1。结论中国居民成人饮酒者全人群的抗雄激素作用样PAEs的累积暴露健康风险较低,有24例个体的健康风险需要关注,建议适量饮酒。
Objective To evaluate the anti-androgen-like phthalate esters of Chinese resident white wine drinkers (hereinafter referred to as drinkers), namely di-2-ethylhexyl phthalate (DEHP) Butyl diethanolamine (DBP), butyl benzyl phthalate (BBP), and their health risks. Methods Based on the data of DEHP, DBP and BBP in 24 kinds of foods collected from 2011 to 2013 and the survey data of nutrition and health status of Chinese residents in 2002, the simple distribution evaluation method was used to calculate the total population of Chinese adult residents drinking alcohol as well as 18 ~ Dietary intakes of DEHP, DBP, and BBP in four age groups (male and female), aged 60 and over (male and female) in four different gender-age groups. The hazard index method was used to calculate the health risks associated with dietary exposure to DEHP, DBP and BBP. Results The risk assessment of single chemical showed that the average intakes of DEHP, DBP and BBP and the intake of high food consumption population (P97.5) of the total population and the gender-age groups of adults in our country were both Below its corresponding daily tolerable intake (TDI). Further analysis found that approximately 0.64% (18/2 800) of individuals had DBP in excess of their TDI. The cumulative risk assessment using the hazard index method found that the hazard index of all adults in China’s drinkers and all age groups was less than 1, and 0.79% (22/2 800) of individuals had more than one hazard index. Conclusion The anti-androgen-like effect of anti-androgen-like anti-androgen-like PAEs in Chinese population is lower than that of healthy people. There are 24 cases of individual health risks need attention, it is recommended that moderate drinking.