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胃肠道间质瘤(g astrointestinal stromal tumors,GIST)是一组消化道间叶性肿瘤,曾经常被认为是平滑肌瘤,平滑肌肉瘤等。1983年最终由梅热(M azur)和克拉克(C lark)确定诊断并命名,他们发现其既无平滑肌分化又无神经源性分化的抗原表达和超微结构,后命名为“胃肠道间质瘤”。随着免疫组化以及电镜技术的发展,G IST的诊断和治疗有了新的认识。GIST组织学上有梭形细胞、上皮样细胞、偶或多形性细胞排列成束状或弥漫状图像。免疫表型上表达C-kit基因蛋白产物KIT,由突变的C-kit
GIST as a gastro stromal tumor (GIST) is a group of gastrointestinal mesenchymal tumors, has often been considered as leiomyoma, leiomyosarcoma and so on. In 1983, M azur and Clarke were finally diagnosed and named. They found that they had neither smooth muscle differentiation nor neurogenic differentiation of antigen expression and ultrastructure, and were later named “gastrointestinal tract Stromal tumor”. With the development of immunohistochemistry and electron microscopy, G IST has gained a new understanding in diagnosis and treatment. GIST histologically spindle cells, epithelioid cells, even or pleomorphic cells arranged in bundles or diffuse images. Immunophenotypically expressed C-kit gene protein product KIT, by mutated C-kit