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本文研究了44例急性下呼吸道感染患儿循环内皮细胞(CEC)的改变。结果表明:正常儿童组(46例)为5.5±2.1n/0.9μl,气管、支气管炎组(16例)为7.7±2.8n/0.9μl,肺炎组(28例)为11.3±4.7n/0.9μl。正常儿童组分别与气管、支气管炎组及肺炎组相比较,差异非常显著(P<0.01)。气管、支气管炎组与肺炎组差异显著(P<0.05)。提示急性下呼吸道感染时存在血管内皮细胞损伤的现象,CEC 数量多少与病情轻重有一定的关系,尤其在缺氧明显的严重感染时患儿 CEC 数量增多更明显。CEC 是目前在活体内唯一可以特异而直接地反映血管损伤的指示物。
In this paper, 44 cases of acute lower respiratory tract infection in children with circulating endothelial cells (CEC) changes. The results showed that the normal children group was 5.5 ± 2.1n / 0.9μl in 46 cases, 7.7 ± 2.8n / 0.9μl in trachea and bronchitis group, and 11.3 ± 4.7n / 0.9 in pneumonia group (28 cases) μl. The difference between the normal children group and the trachea, bronchitis group and pneumonia group was significant (P <0.01). There were significant differences between trachea, bronchitis group and pneumonia group (P <0.05). It is suggested that there is a phenomenon of vascular endothelial cell injury in acute lower respiratory tract infection. The number of CEC and the severity of the disease have a certain relationship, especially when the number of CEC in children with severe hypoxia is obviously increased. CEC is the only indicator in vivo that can specifically and directly reflect vascular injury.