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目的探讨检测老年梅毒感染患者血清抗核抗体(ANA)的临床意义。方法选择2013年1月-2014年12月在本院就诊或住院的264例老年梅毒感染患者为研究对象,200例血清梅毒抗体检测结果为阴性的老年健康体检者为对照组,用间接免疫荧光法(IFA)对2组老年人血清中的ANA进行检测,统计分析2组老年人ANA阳性率和核型分布。结果老年梅毒感染患者中125例ANA阳性,阳性率为47.3%,而健康对照组老年人中33例ANA阳性,阳性率为16.5%;梅毒抗体阳性组老年人ANA阳性率明显高于健康对照组,差异有统计学意义(P<0.05)。梅毒抗体阳性合并ANA阳性老年患者中,ANA核型以染色体型和胞浆颗粒型为主。结论老年梅毒感染患者往往合并自身免疫反应,检测ANA有利于评估和防治老年梅毒感染患者自身免疫性疾病的发生。
Objective To investigate the clinical significance of detecting serum anti-nuclear antibody (ANA) in elderly patients with syphilis infection. Methods A total of 264 elderly patients with syphilis who were hospitalized or hospitalized in our hospital from January 2013 to December 2014 were selected as the study subjects, and 200 healthy subjects with negative serum syphilis antibody test were selected as the control group. Indirect immunofluorescence Method (IFA) ANA in the serum of two groups of elderly were detected, the positive analysis of ANA positive rate and karyotype distribution in two groups of elderly. Results 125 elderly patients with syphilis infection were positive for ANA, the positive rate was 47.3%, while 33 healthy controls were positive for ANA, the positive rate was 16.5%. The positive rate of ANA in elderly patients with syphilis antibody was significantly higher than that in healthy controls , The difference was statistically significant (P <0.05). Syphilis antibody positive ANA-positive elderly patients, ANA karyotype chromosome and cytoplasmic granular predominance. Conclusion In elderly patients with syphilis infection often combined with autoimmune reactions, detection of ANA is helpful to evaluate and prevent the occurrence of autoimmune diseases in elderly patients with syphilis infection.