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目的:探讨硝呋太尔阴道栓与克拉霉素片联用对非淋菌性宫颈炎患者的疗效及其对血清炎症因子的影响。方法:选取医院2015年10月—2016年10月期间收治的非淋菌性宫颈炎患者88例,依据入院先后顺序将其分为观察组与对照组(每组44例);对照组患者给予克拉霉素片治疗,观察组患者在对照组治疗基础上给予硝呋太尔阴道栓治疗,评价两组患者治疗后的总有效率及其对血清炎症因子的影响。结果:治疗前两组患者的白介素-8(IL-8)、肿瘤坏死因子(TNF-α)测得值经组间比较其差异无统计学意义(P>0.05);治疗后观察组患者的IL-8、TNF-α测得值明显小于对照组(P<0.05),治疗后的总有效率明显高于对照组(P<0.05)。结论:采用硝呋太尔栓与克拉霉素片联用治疗非淋菌性宫颈炎患者,改善了患者血清炎症因子各指标,临床疗效优于单用克拉霉素的疗效。
Objective: To investigate the curative effect of nifuratel vaginal suppository combined with clarithromycin on patients with non-gonococcal cervicitis and its influence on serum inflammatory factors. Methods: Eighty-eight patients with non-gonococcal cervicitis admitted from October 2015 to October 2016 in our hospital were divided into observation group and control group (44 cases in each group) according to the sequence of hospital admission. The patients in control group were given carat The patients in the observation group were treated with nifuratel vaginal suppository. The total effective rate and the influence on serum inflammatory factors of the two groups were evaluated. Results: The levels of IL-8 and TNF-α in the two groups before treatment were not significantly different between the two groups (P> 0.05). After treatment, the levels of IL-8 and TNF- The measured values of IL-8 and TNF-α were significantly lower than those of the control group (P <0.05). The total effective rate after treatment was significantly higher than that of the control group (P <0.05). Conclusion: The combination of nitrofurantil suppository and clarithromycin tablets in the treatment of non-gonococcal cervicitis patients, improve the serum inflammatory factors in all indicators, the clinical efficacy is superior to the effect of clarithromycin alone.