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目的:探讨并比较发作期和临床治愈期的抑郁症(major depressive disorder，MDD)患者静息态下缰核的功能连接(functional connectivity，FC)特征。方法:对35例发作期抑郁症患者(first-episode current MDD，fMDD)、35例经住院治疗达到临床治愈期抑郁症患者(remitted MDD，rMDD)和性别、年龄、教育年限相匹配的30例健康对照被试(healthy controls，HC)进行静息态fMRI扫描。使用汉密尔顿抑郁量表(HAMDn 17)评估患者的严重程度。以缰核为感兴趣区进行FC分析，比较组间差异，并对差异脑区FC值与病程、HAMDn 17评分之间进行Pearson相关分析。n 结果:(1)与HC组相比，fMDD组缰核与左侧枕中回(x，y，z＝-48，-84，3，n t＝-4.335，n P<0.05)FC减低，缰核与左侧缘上回(x，y，z＝-66，-30，36，n t＝4.876，n P<0.05)、左侧额上回(x，y，z＝-6，-33，51，n t＝4.402，n P<0.05)、双侧顶下小叶(左侧：n t＝3.300，n P<0.05，右侧：n t＝3.557，n P<0.05)FC增强；与HC组相比，rMDD组缰核与左侧枕中回(x，y，z＝-48，-84，3，n t＝-4.321，n P<0.05)、左侧丘脑(x，y，z＝-9，3，3，n t＝-3.971，n P<0.05)FC减低，缰核与左侧颞中回(x，y，z＝-48，-39，9，n t＝4.062，n P<0.05)、左侧缘上回(x，y，z＝-51，-15，45，n t＝2.906，n P<0.05)、左侧额上回(x，y，z＝-24，-21，39，n t＝3.044，n P<0.05)、双侧顶下小叶(左侧：n t＝2.880，n P<0.05，右侧：n t＝3.512，n P<0.05)FC增强；(2)fMDD组缰核与右侧眶额皮层(n t＝-3.899，n P<0.05)、左侧颞中回(n t＝-4.023，n P<0.05)功能连接低于rMDD组，缰核与左侧缘上回(n t＝4.157，n P<0.05)、左侧额上回(n t＝3.327，n P<0.05)、左侧丘脑(n t＝3.316，n P<0.05)、左侧顶下小叶(n t＝3.909，n P<0.05)FC高于rMDD组；(3)Pearson相关分析显示，以上差异脑区FC值与HAMDn 17总分均无相关性，缰核与左侧枕中回FC值与病程具有边缘相关性(n r＝0.328，n P＝0.063)。n 结论:发作期与临床治愈期MDD患者缰核与默认网络、视觉网络、奖赏网络功能连接异常，可能参与抑郁症的发病机制。rMDD患者缰核功能连接未恢复正常。“,”Objective:To investigate the difference of functional connectivity(FC) between the habenula and other brain regions in the patients with first-episode current depression (fMDD) and remitted depression (rMDD).Methods:Thirty-five patients with first-episode current depression (fMDD), 35 patients with remitted depression (rMDD) and 30 healthy controls (HC) matched with gender, age and education years were scanned by resting-state fMRI. Hamilton Depression Scale (HAMDn 17) was used to assess the severity of the patients. After preprocessing, seed-based FC analysis was performed on the habenula. Pearson correlation analysis was performed between the FC values and HAMDn 17 and duration of disease.n Results:(1) Compared with the HC group, FC decreased between the habenula and left middle occipital gyrus(l-MOG) in fMDD group (x, y, z=-48, -84, 3, n t=-4.335, n P<0.05), while FC increased between the habenula and left supramarginal gyrus (x, y, z=-66, -30, 36,n t=4.876, n P<0.05), left superior frontal gyrus(l-SFG) (x, y, z=-6, -33, 51,n t=4.402, n P<0.05), left inferior parietal lobe(l-IPL)(n t=3.300, n P<0.05) and right inferior parietal lobe(r-IPL) (n t=3.557, n P<0.05) in fMDD group. Compared with the HC, FC decreased between the habenula and l-MOG (x, y, z=-48, -84, 3,n t=-4.321, n P<0.05) and left thalamus (x, y, z=-9, 3, 3,n t=-3.971, n P<0.05) in rMDD group, while FC increased between the habenula and left middle temporal gyrus(l-MTG)( x, y, z=-48, -39, 9,n t=4.062, n P<0.05), left supramarginal gyrus (x, y, z=-51, -15, 45,n t=2.906, n P<0.05), l-SFG (x, y, z=-24, -21, 39,n t=3.044, n P<0.05), l-IPL (n t=2.880, n P<0.05) and r-IPL (n t=3.512, n P<0.05) in rMDD group. (2) FC decreased in fMDD group between the habenula and right orbitofrontal cortex(r-OFC) (n t=-3.899, n P<0.05) and l-MTG (n t=-4.023, n P<0.05) than rMDD group, while FC increased between the habenula and left supramarginal gyrus (n t=4.157, n P<0.05), l-SFG(n t=3.327, n P<0.05), left thalamus (n t=3.316, n P<0.05) and l-IPL (n t=3.909, n P<0.05) than rMDD group. (3)There was no significantly correlation between the HAMDn 17 and the FC value changes among the different regions, and was marginal significantly correlation between duration of disease and the FC values from the habenula and l-MOG(n r=0.328, n P=0.063).n Conclusion:Both fMDD and rMDD show abnormal FC between the habenula and default mode network, visual network and reward network, which may be related to the pathogenesis of depression. The FC of the habenula in rMDD still had not recovered to normal.