Background Laparoscopic splenectomy (LS) for massive splenomegaly is more technically challenging than for a normal-sized spleen.The purpose of this study was to determine the effect of operative experience on perioperative outcomes of LS for massive splenomegaly.Methods Between January 2008 and December 2010,36 consecutive patients who were diagnosed with massive splenomegaly underwent LS in our department.The perioperative outcomes were evaluated for evidence of a leing curve effect.Patients were divided into three groups (1,2,and 3) of 12 consecutive patients,and outcomes of each group were compared.Results The mean operative time decreased significantly from 252 minutes of Group 1 to 179 minutes of Group 3.The estimated blood loss and length of post-operative hospital stay showed a similar trend.No significant differences were found in the splenic length and weight,transfusion rate,or average amount of drainage.In this cohort,there were three cases with surgical complications and one conversion to open laparotomy.Conclusions The first 24 cases constitute the early stage of the leing curve for LS for massive splenomegaly.LS for massive splenomegaly is a technically challenging operation with a long leing curve,and strategies for developing training programs must address these challenges.