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目的 比较氟铁龙与氟脲嘧啶对晚期消化道癌的疗效。方法 42例晚期消化道癌随机分为治疗组和对照组 ,治疗组用氟铁龙加丝裂霉素化疗 ,对照组用氟脲嘧啶加丝裂霉素化疗。 2～ 3周期后评价疗效与毒副反应。结果 治疗组有效率为 61.9% ,对照组为 3 8.1%。两组差异无显著性。两组毒副反应均表现为白细胞下降与恶心、呕吐等 ,差异无显著性。结论 氟铁龙加丝裂霉素联合化疗 ,对晚期消化道癌是一疗效较高和较安全的方案。
Objective To compare the efficacy of fluorouracil and fluorouracil on advanced gastrointestinal cancer. Methods Forty-two patients with advanced gastrointestinal cancer were randomly divided into treatment group and control group. The treatment group was treated with ferrion plus mitomycin and the control group was treated with fluorouracil plus mitomycin. After 2 to 3 cycles, efficacy and toxicity were evaluated. Results The effective rate in the treatment group was 61.9% and that in the control group was 3.8%. There was no significant difference between the two groups. Both toxicities and side effects were manifested as leukopenia, nausea, and vomiting, with no significant difference. Conclusion Combined treatment with fiproterone plus mitomycin is a more effective and safer option for advanced gastrointestinal cancer.