有17篇以上的文章指出根尖有病变时,根管治疗的成功率就明显降低,对于这种重要情况文献上讨论不多。首先,根尖有病变的牙髓常有部分坏死,另外还有慢性炎症细胞。这些炎症细胞中的吞噬细胞与淋巴细胞,由于相互影响可产生一组介导质,介导质中的破骨细胞激活因子(OAF)可引起骨质吸收。Laogeland等证明,这种吸收性介导质或细胞毒素能通过健康组织吸收骨, There are more than 17 articles pointed out that the root tip lesions, the success rate of root canal treatment significantly reduced, for this important situation in the literature discussed. First of all, the root tip of the diseased pulp often partial necrosis, in addition to chronic inflammatory cells. These inflammatory cells in phagocytes and lymphocytes, due to interaction can produce a group of mediators, mediating the osteoclast activation factor (OAF) can cause bone resorption. Laogeland et al. Demonstrated that this absorptive mediator or cytotoxin can absorb bone through healthy tissues,