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CD30L(CD153)是肿瘤坏死因子超家族(TNFSF)中的一个成员,属Ⅱ型跨膜蛋白,其胞膜外区与其他TNFSF成员(如TNF-α、LT-α和CD40L等)有较高同源性,主要表达于活化T细胞、单核/巨噬细胞、中性粒细胞,以及某些髓系和淋巴系起源的造血系统的恶性肿瘤细胞。CD30L结合其受体CD30,介导分
CD30L (CD153) is a member of the tumor necrosis factor superfamily (TNFSF) and belongs to type II transmembrane protein. Its extracellular domain has high homology with other TNFSF members (such as TNF-α, LT-α and CD40L) Sexually expressed mainly in activated T cells, monocytes / macrophages, neutrophils, and some malignant cells of the hematopoietic origin of myeloid and lymphatic origin. CD30L binds to its receptor CD30, mediating fractions