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目的研究卡托普利与美托洛尔治疗慢型克山病及对患者心脏功能的影响对比。方法 153例慢型克山病患者,采取随机数字表法分成A、B、C三组,各51例。C组施以利尿剂、洋地黄类制剂等常规药物治疗,A组在常规基础上施以卡托普利治疗,B组则改用美托洛尔治疗,比较三组临床疗效。结果 A、B两组在心率、Tei指数、舒张压、BNP、异位心律消失率及LVEF值方面均显著优于C组(P<0.05);B组在心率以及ST-T改变的消失率方面较之于C组存在显著优势(P<0.05);A、B两组在ST-T改变的消失率、心率、Tei指数、舒张压、BNP、心率、异位心律消失率及LVEF等比较差异无统计学意义(P>0.05)。结论美托洛尔和卡托普利能有效改善慢型克山病患者心脏功能,安全性高,值得在临床上推广应用。
Objective To compare the effects of captopril and metoprolol on chronic Keshan disease and its cardiac function. Methods A total of 153 patients with chronic Keshan disease were randomly divided into three groups (A, B and C), with 51 cases in each group. Group C was given diuretics, digitalis preparations and other conventional drug treatment, A group on a routine basis with captopril treatment, B group was replaced with Metoprolol treatment, the clinical efficacy of the three groups were compared. Results The heart rate, Tei index, diastolic blood pressure, BNP, ectopic rhythm disappearance rate and LVEF value in group A and group B were significantly better than those in group C (P <0.05). The disappearance rate of heart rate and ST-T in group B (P <0.05). Compared with group C, the disappearance rate, heart rate, Tei index, diastolic blood pressure, BNP, heart rate, ectopic rhythm disappearance rate and LVEF in group A and group B were compared The difference was not statistically significant (P> 0.05). Conclusion Metoprolol and captopril can effectively improve cardiac function in patients with chronic Keshan disease, which is safe and worth popularizing in clinic.