癫痫是一组慢性临床综合征,以在长期病程中有反复发作的神经元异常放电所致的短暂脑功能失常为特征。脑电图和微电极技术结合的研究证明,癫痫发作的电生理本质是脑神经元过度同步放电的结果。Heineman等在实验性癫痫中使用离子敏感微电极研究方法证实:癫痫发作时,细胞外钙离子(Ca~(2+))立即下降(从静息水平1.2～1.3降至0.1～0.9nmol),细胞内钙 Epilepsy is a group of chronic clinical syndromes characterized by transient brain dysfunction caused by abnormal firing of neurons that have recurrent episodes in the long term. EEG and microelectrode technology combined studies have shown that the electrophysiological nature of seizures is the result of excessive synchronic firing of neurons in the brain. Heineman and his colleagues used ion-sensitive microelectrode studies in experimental epilepsy to demonstrate that immediately after epileptic seizures, the extracellular calcium (Ca2 +) decreased (from resting 1.2-1.3 to 0.1-0.9 nmol) Intracellular calcium