近年来,随着分子生物学、分子药理学的不断发展,新型的抗肿瘤药物不断涌现,如嘧啶衍生物等作为具有抗肿瘤代谢作用的药物已受到医学界的关注[1,2],其中2,4-二取代嘧啶已被证明具有强力的抗肿瘤活性,因此,对2,4-二取代嘧啶的研究就显得十分重要[3]。本文就2-甲氧基-4-取代嘧啶类化合物的制备与应用论述如下。 In recent years, with the continuous development of molecular biology and molecular pharmacology, new types of antitumor drugs have emerged such as pyrimidine derivatives and the like as anti-tumor metabolism drugs that have drawn the attention of the medical community [1,2] 2,4-disubstituted pyrimidine has been shown to have potent anti-tumor activity, therefore, the study of 2,4-disubstituted pyrimidine is very important [3]. In this paper, the preparation and application of 2-methoxy-4-substituted pyrimidines are discussed as follows.